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Leptomycin B, 0.5 MG

Price$ 120.25
  • SKU: L-1069-0.5MG
  • Pack Size: 0.5 MG
Quantity
-
+

LMB; Elactocin

87081-35-4

540.7

C33H48O6

Ethanol, Methanol

-20°C


Leptomycin B is an antibiotic that is used for studying nuclear localization and nuclear export. Specific inhibition of the CRM1/exportin1 nuclear export pathway. It also demonstrates anti-fungal anti-tumor activity.
 

Leptomycin B is the dominant and most studied member of the leptomycin class, isolated from selected Streptomyces strains. Leptomycin B is a nanomolar active and specific nuclear export inhibitor. Its target is CRM1/exportin1, a protein in the nuclear export sequence (NES). Proteins affected include c-Abl, cyclin B1, HIV-1 Rev, IκB, MPF, MAP/ERK, MDM2/p53, NF-κB/IκB7 and PKA. Leptomycin B inhibits export of many RNAs, e.g. COX-2 and c-FOS mRNA.

Leptomycin B also shows antifungal, antibacterial and potent antitumor activities.


 

0.1 lbs



Research or further manufacturing use only, not for food or drug use.

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